Risk factors for developmental defects of enamel in children from southeastern Brazil

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  • Caio L. B. Reis
  • Mariane C. F. Barbosa
  • Daniela C. de Lima
  • João A. Brancher
  • Célia M. C. F. Lopes
  • Flares Baratto-Filho
  • Erika C. Küchler
  • Daniela S. B. de Oliveira


Introduction: Developmental Defects of Enamel (DDEs) comprise qualitative and/or quantitative changes to the enamel during amelogenesis.
The aetiology of DDE remains inconclusive. Aim: To determine the association of pre, peri, and postnatal factors with the presence of
DDE. Design: Cross-sectional study with 353 children (8 to 11 years-old) in a Brazilian town. Methods: One calibrated dentist assessed
DDE using the Developmental Defects of Enamel Index and a questionnaire collected medical and sociodemographic data. Main outcomes:
Children with at least one type of DDE were categorized into the DDE group. Subtypes of DDE were also recorded. Results: 63.1% of
children had at least one type of DDE. Diffuse opacity was present in 36.7%, demarcated opacity in 14.8%, and hypoplasia in 5.83% of
the children. In multivariate analysis, demarcated opacities and hypoplasia were associated with birth weight < 2500g (OR = 4.82; 95%
CI 1.23-1.95). Conclusion: Low birth weight predicted DDE.

Keywords: Growth and Development, Dental Enamel Hypoplasia, teeth abnormalities, Tooth Hypomineralization, Odontogenesis Prenatal
Injuries, Neonatal Diseases

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